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KMID : 0032220020140020082
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Annals of Dermatology
2002 Volume.14 No. 2 p.82 ~ p.87
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Combination Therapy with Intralesional Interferon α-2b and Pulsed Dye Laser for the Treatment of Periungual Warts
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박정훈:Park Jeong-Hun
김영근:Kim Young-Keun/최광성:Choi Gwang-Seong
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Abstract
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Background : Periungual warts are a therapeutic challenge. Many studies have revealed that intralesional interferon α-2b therapy and pulsed dye laser therapy have numerous advantages over other modalities of theratment.
Objective : The purpose of this study was to determine if combination therapy with intralesional interferon α-2b and pulsed dye laser might offer an effective treatment for periungual warts.
Methods : Thirty-three patients were randomly assigned to one of three study groups. In group A, the patients received both intralesional interferon α -2b treatment and pulsed dye laser(PDL) therapy (n=13). Group B patients were treated wit intralesional interferon α -2b alone (n=10) and group C was done with PDL therapy only (n=10).
Results : The clearance rate was 92.3% for the patients treated with the combination therapy of intralesional interferon α -2b treatment and pulsed dye laser (PDL) therapy. It was 50% for the patients with the intralesional interferon α -2b treatment alone, and 0% for the group with the PDL therpy only. No significant side effects were observed. At 6 months after cessation of the therapy, total 2 cases (one from group A and the other from group B) were recurred.
Conclusion : The combination therapy with intralesional interferon α -2b treatment and pulsed dye laser therapy was highly effective for the treatment of recalcitrant periungual warts.
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KEYWORD
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Combination therypy, Interferon α-2b, Periungual warts, Pulsed dye laser,
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